ThreatLocker has resolved this issue in Agent Version 7.8.
The ThreatLocker Development team is working to develop a solution within Tamper Protection to avoid needing the exclusions in the future.
There has been a reported issue regarding backups failing because Tamper Protection is restricting the backup software's access to ThreatLocker files. This is caused by the backup software trying to access the ThreatLocker files in manner that is blocked by Tamper Protection.
Exclusions to the ThreatLocker files, as seen in our Working with Your Existing Antivirus | ThreatLocker Help Center (kb.help) , added to your backup software should mitigate this issue.